Enhancing bile tolerance of Lactobacilli is involved in the hypolipidemic effects of liraglutide

ABSTRACT Liraglutide is an analog of human glucagon-like peptide-1 which play essential roles in regulation glycolipid metabolism. To investigate role lactic acid bacteria (LAB) lipid-lowering effect liraglutide, 40 mice were divided into normal food diet (NFD), high-fat (HFD), 10.0 mg/kg/d simvastatin-treated HFD (SIM + HFD), 200 and 400 µg/kg/d liraglutide-treated (LL HL HFD) groups for 5 weeks. We found that liraglutide could upregulate cholesterol 7α-hydroxylase (CYP7A1) LDL-receptor (LDLR), whereas downregulate 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Besides, enhance abundance lactobacillaceae gut hyperlipidemic increase bile tolerance ability LAB by upregulating salt hydrolases, the lysate liraglutide-sensitive also directly HMGCR, key enzyme synthesis, inhibit hepatocyte steatosis. These findings might provide new theoretical guidance clinical application research development antiobesity, hypolipidemic, cholesterol-lowering drugs or functional foods.